Curious HumaN |Phd candidate in pathobiologY
A day in the life of a drosophila biologist!
The first part of the video shows a classic method in drosophila research known as fly flipping because you flip flies from one vial of food to another with fresh food so they can remain healthy! It’s common vernacular for drosophila researchers to ask for a “flip” of flies when they are in need, meaning a vial of them!
The second part of the video shows a process fondly known in the fly community as fly pushing, where you use C02 as anesthesia to sort flies based on things like phenotypic markers (for example you can distinguish whether a fly is carrying a genetic mutation by eye color! It’s called fly pushing because you can use a paintbrush or feather to push your flies as you sort.
click the link below!
https://vimeo.com/440196447
https://youtu.be/jmbx4uyqzWw?si=KTETPwguyOPtOnNs
Earlier this month I presented my work at a conference for the first time at the inaugural Tau2020 Global Conference and it was one of the most fruitful experiences I’ve had in my grad student life so far! It was amazing to see 600 scientists all gathered to discuss one extremely complicated protein: Tau. I learned so much from the experts in this field who were more than willing to share data, tools, and discuss which questions remain to be answered. The role of the immune system in tauopathy pathogenesis seems to be a very compelling avenue to pursue , which has made me even more excited about what questions my PhD research may help to answer. The work I presented was on altered innate immunity in a novel Drosophila model of primary tauopathy. I’m incredibly grateful to the Alzheimer’s Association (Twitter: @alzassociation) for awarding me a fellowship to attend this conference, and I cannot wait for the next one!
Information for the conference can be found here: https://tauconsortium.org/initiative/tau2020-globalconference/
I’m thrilled to be one of the 2019 BAD Meeting Organizers. I just began working with Drosophila as a model organism this summer and I have fallen in love with them, so I am very excited to commiserate and learn from local Drosophila enthusiasts this summer. The meeting will be held June 11th 2019 at 95 Cushing St. Providence, RI (Brown University)
Check out the information from the BAD website at : https://bostonareadrosophilameeting.com/
I have officially joined two research groups! I will be co-supervised by Dr. Marc Tatar and Dr. Karla Kaun.
I am so incredibly excited to really get to dig deep into a project with such a stimulating and creative group of scientists! I am especially thrilled because of how interdisciplinary the two groups are. Members of the labs span the departments of Ecology and Evolutionary Biology, Neuroscience, Molecular and Cellular Biology, and Molecular Pharmacology, Physiology, and Biotechnology.
I feel so grateful to be able to explore one of the most elusive mysteries in biology: the brain. And due to working with experts in such wide ranging fields, we will be able to explore neuropathology from a myriad of perspectives, and I get to be one of these lab coat wearing scientists! Together maybe we can figure out the elephant that is neurodegenerative disease!
One of the perks of being a grad student at Brown is the amazing colleagues and friends you make. This is one inspirational group!
Looking back on my very short career so far in science I have realized that above all one key to success is mentorship. This is especially true as a woman in science, as we truly do stand on the shoulder's of the female scientists that came before us and shattered glass ceilings that made our careers a possibility instead of a distant dream. I have been extraordinarily lucky by having fantastic mentorship throughout my studies and lab work which have also translated into my non-professional life. Because of this, I am writing my first blog post first to thank all of my mentors over the years, to describe what I believe to have been the most helpful to me, and finally to define ways I can pay this amazing mentorship forward.
The first clearly defined mentor I had was Dr. Erica Bree Rosenblum at U.C. Berkeley. I could not have asked for a more enthusiastic, caring, and skilled mentor. At the time I was looking for a lab in which I could conduct my senior thesis, I knew I was interested in ecology, but never had any real research experience, except for my own small field projects in biology classes. I scoured the ecology lab websites at Berkeley and was immediately fascinated by her research on rapid evolution of lizards at White Sands National Park. I e-mailed her asking if she had time to meet to discuss her research more as I was looking for something to write my thesis on. Bree quickly responded and we set up a meeting time. Perhaps this is also where luck came in for me as a young hoping-to-be scientist. Not everyone you e-mail to chat about their work will have the time to write you back, but in this case, Bree was a new faculty and I happened to be the first undergraduate to reach out to her. After interviewing over skype with her graduate students, I was invited to do field research in White Sands and given an NSF REU grant for my thesis research.
Bree responding to my e-mail completely changed the trajectory of my life. The main reason was that someone I admire greatly and aspired to be like believed in me, which in turn made me believe in myself. Belief in myself gave me the confidence to explore and express my scientific ideas and theories which is what is truly at the root of being a scientist.
In the Rosenblum lab I worked directly for Dr. Simone Des Roches, who at the time was the graduate student I worked for and she became a second mentor and now life long friend. From Simone I learned that a mentor extends beyond an academic teacher. Simone taught me about how to conduct research, she showed me the inner workings and relationships within academia. More importantly she showed me how to survive the pressures of pursuing a career in science by prioritizing relationships and hobbies along with work. It's very easy to idealize the mantra that if working hard an sacrificing everything else, but in the long run this never leads to a happy life which in turn leads to more fulfilling and clear eyed research.
My next mentor embodied a balanced lifestyle was Dr. Hilary Thomas at the University of California at San Francisco in Dr. Jeff Bluestone's Lab. She headed up a Type 1 Diabetes clinical trial and hired me as a research assistant. Hilary became a clinical principal investigator, managed our research projects, and had a lovely family to boot. She showed me that it is possible-with the correct prioritization and mastering workflow efficiency- that a researcher can have a fulfilled balanced life. She helped me through my mistakes by showing me that sometimes taking breaks can actually improve efficiency and quality of work when I got stuck on certain assays (which is something I still struggle with but am getting better at learning when I need to take a break!)
While in Dr. Bluestone's lab I developed mentor-mentee relationships with other post-docs, medical fellows, and specialists who all showed me the value of believing that your work will actually make the world a better place. When you are surrounded by experienced people who believe in their work and have an emotional connection and drive to succeed in order to help others, you learn that genuine desire to help others drives the greatest research and provides the energy required to do thorough and impactful research. This aspect of mentorship is the most important and inspiring to me as a young scientist starting out my own independent research. I truly feel that if you believe that your findings from your research will help others and that is the main driver of your work, then, like my mentors, you will be able to carry on even through the most disenchanting parts of scientific studies. Observing the passion and drive of my mentors I have realized that I share that same enthusiasm and devotion to helping others.
Each and every mentor I have has greatly impacted my goals and values both academically, scientifically, ethically, and personally. I believe that the mentor-mentee relationships are one of the most important and precious relationships that any young ambitious person can have. I thank all of my mentors for teaching me invaluable lessons and believing in me, and I hope that one day I can pay it forward to other young scientists.
"The grandeur of life is in the attempt"- Toni Morrison
